Is the CBD vs. CBG criteria worth considering in your medical cannabis practice? Yes, if you want a comprehensive and holistic approach to healthcare.
Remember, most patients seek to maximise the therapeutic potential of cannabis. Strive to leave no stone unturned in addressing this pain point.
Since the legalisation of medicinal cannabis in 2016, prescriptions have continued to soar. In 2022, doctors assisted 316,879 patients, up from 150,117 in 2021. So far, Australia has recorded over a million prescriptions.¹
As Australians embrace this natural treatment alternative, exploring its components is imperative. Medicinal cannabis primarily comprises CBD and cannabigerol (CBG). These two compounds carry significant medicinal potential, and ongoing research is promising.
The Australian regulatory landscape requires a meticulous approach to prescriptions. Why should you keep up-to-date with the latest research? Practitioners who are well-versed in the latest clinical research navigate it seamlessly.
Evidence-based prescriptions for medical practitioners cater to patient well-being. It helps you make informed decisions while boosting credibility.
How do you get started? Discover the medicinal dynamics of CBG and CBD in this clinical guide.
Understanding CBD and CBG: Key differences and similarities
CBD and CBG are both cannabinoids found in the cannabis plant. Besides THC, this plant has over 100 other cannabinoids.² These compounds have diverse roles, including potentially relieving some medical conditions.
Unlike THC, CBD is a non-psychoactive compound. It typically accounts for about 40% of the plant resin extract, but it can be anywhere from 0–100% in different strains.³ This cannabinoid is among the most studied for its diverse therapeutic properties.
CBG is also a non-psychoactive compound in cannabis. It’s derived from young cannabis plants in smaller quantities than CBD.⁴ Some enthusiasts call it the “mother of all cannabinoids.” Its acidic form (cannabigerolic acid) gives rise to other cannabinoids.
While research on CBG benefits is growing, it carries immense therapeutic potential. Medical practitioners can leverage this knowledge to diversify their clinical recommendations.
Both compounds display their medicinal potential by interacting with cannabinoid receptors. They may induce healing properties without mood or perception alteration commonly associated with THC.
Cannabinoid receptors feature in different sections of the central nervous system (CNS). The human body has two primary receptors: CB1 and CB2.⁵ The effects of either cannabinoid depend on the brain area targeted.
Despite CBG and CBD benefits, what are the legal considerations for medical practitioners?
Australia only permits medicinal cannabis use under a healthcare expert’s guidance.⁶ You can only prescribe it for conditions backed by satisfactory scientific evidence supporting its use.
The Therapeutic Goods Administration (TGA) oversees cannabinoid prescriptions. The Office of Drug Control authorises the import of medicinal cannabis products. You can only make CBD prescriptions for certain conditions through these two schemes.⁷
- Special Access Scheme (SAS)
- Authorised Prescriber (AP) scheme
The therapeutic potential of CBD
CBD clinical applications are diverse thanks to in-depth scientific research. Below, we highlight popular areas where CBD shows promise.
Pain management
Did you know that 20% of adults worldwide endure chronic pain? An additional 10% of adults complain of chronic pain each year.⁸ While most folks consider physical therapy and antidepressants, CBD may be worth trying.
Several research reviews show cannabinoids as potential chronic pain relievers. Patients who took CBD saw a substantial reduction in pain symptoms. They ended up perceiving CBD as a worthy alternative to conventional pain medications.
Another research study shows CBD can treat chronic pain in many conditions.⁹ It’s a suitable alternative for addressing persistent chronic pain.
Scientists say it’s well-tolerated, as it lacks the psychoactive influence. It’s better suited to relax muscles by suppressing inflammatory pain.
Anxiety and stress reduction
About 4% of the world’s population experiences anxiety disorders.¹⁰ These conditions top the list of mental health issues. Most people turn to stress management and relaxation therapies for relief.
Some studies say CBD could ease anxiety-related disorders. It binds to the endocannabinoid system, inhibiting its signalling.¹¹ This action helps control stress responses, adding resilience against stress exposure.¹²
In this research, CBD proved effective due to its minimal adverse effects. Being a well-tolerated remedy, it translated to improved anxiety responses.
Another study shows that CBD may have analgesic and anxiolytic properties. Some 400 patients with anxiety and chronic pain took it and noted improvement. There was a significant reduction in anxiety and depression symptoms. Better appetite and sleep were also noted.
Anti-inflammatory properties
The use of CBD in medical practice extends to potential inflammation treatment. Scientists say CBD activates the body’s CB2 receptors.¹³ This intervention helps reduce reactive oxygen species (ROS). The aftermath is a decline in oxidative stress and inflammation.
CBD may enhance the body’s anti-inflammatory effects through the following mechanisms:
- Lowering the levels of pro-inflammatory cytokines
- Inhibiting T cell proliferation
- Lowering migration and adhesion of immune cells
- Inducing T cell apoptosis (cell death)
Some research reviews claim CBD lowers arthritis-related pain and inflammation.¹⁴ This effect comes through topical application. CBD may also ease stubborn neuropathic pain.
The emerging role of CBG in healthcare
CBG is a lesser-known cannabinoid in healthcare, but it’s gaining attention due to its unique properties and potential benefits. Below are its wide-ranging biological activities that may benefit patients.
Neuroprotective effects
While research on CBG is minimal, several findings support its therapeutic potential. It could benefit certain neurological diseases with its neuroprotective effects.
Animal studies show CBG could be a natural antioxidant in neurodegenerative conditions. It protects rat astrocytes from oxidative stress by reducing ROS production. It also restores serotonin levels in the cortex, a hormone that helps convey messages between nerve cells.¹⁵
Ongoing studies explore CBG as an alternative remedy for CNS conditions, like Huntington’s disease.¹⁶ This condition causes the deterioration of brain nerve cells. CBG could improve cell viability and protection.
Antimicrobial properties
CBG clinical applications also leverage its potential antimicrobial properties. The compound expresses anti-bacterial and anti-biofilm activities towards S. mutans.¹⁷ This bacteria species usually features on tooth surfaces, causing tooth decay and enamel deterioration.
A recent study shows CBG may be beneficial to skin health. It inhibits the adhesion of Staphylococci (bacteria) to keratinocytes (skin cells). This antimicrobial effectiveness could also help preserve cosmetic ingredients.
Anti-inflammatory benefits
Most doctors consider CBG in medical practice due to its potential anti-inflammatory effects. A study shows that proper CBG formulations may combat inflammation. The research recommends CBG for diseases tied to airway inflammation.
CBG could boost immunity by inhibiting the activation of pro-inflammatory cells.¹⁸ It may also aid the synthesis of pro-inflammatory mediators. In other words, CBG might lower intracellular and mitochondrial oxidative stress. The aftermath is a significant inflammation decline.
The study also says CBG may have apoptotic effects in tumour cells. It may accelerate the death of tumour cells. It has this impact alone and in combination with CBD.¹⁹
Choosing between CBD and CBG in clinical practice
Both CBD and CBG boast potential therapeutic benefits, but is CBG more effective than CBD? How do you choose between the two in your clinical practice?
Check out the main factors influencing the selection of CBG or CBD below.
Patient characteristics and medical history
Tailor your patients’ cannabinoid selection to their characteristics and medical history by considering these factors:
- Age
- Pre-existing health conditions
- Concurrent medications
- Prior experience with cannabinoids
These elements may affect dosing and potential side effects. They impact how each cannabinoid could interact with a patient’s unique health profile.
Targeted therapeutic outcomes
What are your medical cannabis patients after? Do they seek a potential remedy for pain, anxiety, or inflammation? Are your patients looking for short-term or long-term relief?
Remember, CBD and CBG have varying mechanisms for different conditions. CBD typically displays anxiolytic, anti-inflammatory, and analgesic effects. CBG may be suitable for neuroprotection and microbial protection. Both could target inflammatory activity.
Align these potential therapeutic effects with your patients’ unique needs for optimal results.
Potential side effects and interactions
Both CBG and CBD are generally well-tolerated by most patients. Sometimes, they may exhibit variations due to different metabolic interactions. Understanding these nuances is vital to a safe cannabinoid experience by minimising risks.
Below are some possible CBD side effects:²⁰
- Dry mouth
- Diarrhoea
- Reduced appetite
- Drowsiness
- Fatigue
- May interact with medications like blood thinners
CBG typically causes mild side effects listed below:²¹
- Dry mouth
- Sleepiness
- Increased appetite
- Dry eyes
Dosing considerations for CBD and CBG
Choosing between CBD and CBG also boils down to dosing considerations, which lack a one-size-fits-all approach. Dosing often hinges on individualised treatment plans. Here are a few personalisation pointers for different patients:
- Weight
- Cannabinoid tolerance
- Specific needs
- Severity of the addressed condition
What’s the ideal strategy for CBD vs. CBG in medical prescriptions? Start with a conservative dose. Observe the patient’s response and tolerance and adjust the dosage accordingly.
Cannabinoid dosage titration usually depends on a patient’s response. The safest dosing strategy is starting slow and going slow.²² Maintain the lowest possible dose to satisfy patient needs with minimal side effects.
Provide ongoing patient monitoring to reach an optimal therapeutic dose through adjustments. Remember, different cannabinoid formulations have varying absorption rates and effects. Evaluate your patients based on whether you administer oils, capsules, or topicals.
Personalising CBD and CBG prescriptions
Personalised CBD and CBG prescriptions are essential to a tailored and effective treatment. Below are the two fundamental assessments for making the most of this process.
Comprehensive medical history and current medications
Assessing your patient’s medical history and current medications can avert potential harm. A detailed history should reflect the following:
- Past surgeries
- Chronic conditions
- Allergies
- Relevant mental health diagnoses
- Lifestyle issues (sleep habits, exercise, diet, alcohol intake)
These aspects give you a holistic perspective on the patient’s overall well-being. You can then tailor your cannabinoid therapy to their specific needs.
It’s also crucial to look into the patient’s current medication regimen. Check all their medicines, including over-the-counter pharmaceuticals. Additionally, review their herbal supplements and vitamins to identify possible interactions.
Identifying contraindications and potential interactions
Screen for contraindications to CBD and CBG per the patient’s medical history. Some medications or conditions may preclude the use of these cannabinoids. For example, high CBD doses may not favour patients with severe liver disease.²³
You may also need to go slow in treating patients with a history of cannabinoid sensitivity. Some patients could exhibit signs of CBD allergies.²⁴ Ask if they experience skin irritation when taking the cannabinoid.
Do cannabinoids intensify the side effects of other medications? Sometimes. For instance, taking CBD and sleep-inducing medicines can cause increased sleepiness.²⁵ This cannabinoid may also escalate fatigue when combined with certain herbal supplements.
Consultation and collaboration with other healthcare professionals
Collaborating with healthcare teams affords your patients the best care. Consult experts and specialists in relevant departments for valuable insights.
- Pain management experts
- Neurologists
- Oncologists
Don’t overlook pharmacists. They can offer vital information on possible medication interactions. These professionals may also advise on safe treatment management. Additionally, tell your patient’s primary care physician why you propose CBG or CBD therapy.
Monitoring and adjusting treatment plans with CBD and CBG
Before integrating cannabinoids into patient care, establish a solid framework. Working with this structure optimises outcomes while ensuring patient well-being.
- Implement regular follow-ups
- Monitor CBD and CBG treatment for adverse effects
- Adjust treatment plans
Regular follow-up appointments result in comprehensive assessment. You get to evaluate changes in symptoms and possible side effects. It’s easier to gauge a patient’s overall health status.
Follow-ups also allow you to educate patients on the expected cannabinoid effects. Address any concerns or questions your patients may have during these sessions.
Consistent patient monitoring keeps track of adverse effects and treatment efficacy. Assess the severity of cannabinoid’s impact on patients.
Monitor treatment efficacy by reviewing the targeted therapy outcomes. Leverage patient-reported results and clinical observations to gauge impact.
After effective monitoring, focus on adjusting dosage based on patient response. Acknowledge the possibility of variable responses to cannabinoids. Adapt cannabinoid doses to a patient’s unique characteristics. When ready to adjust a dose, employ gradual titration.
Educating patients on CBD and CBG usage
Patient education on CBD and CBG is a cornerstone for safe and effective cannabinoid use. Here are a few key areas to address.
- Foundational facts. Educate patients on the various sources of CBG and CBD. Elaborate on their dynamic formulations and how to choose the best product.
- Mechanism of action. How do both cannabinoids interact with the body’s endocannabinoid system?
- Tailored benefits. How do CBG and CBD target a patient’s specific needs?
- Legal and regulatory landscape. Paint a picture of the current CBG and CBD laws in your region.
Your patient education should also focus on addressing misconceptions and concerns.
- Psychoactive effects. Clarify that neither CBG nor CBD produces intoxicating effects like THC.
- Legality. Debunk any myths around consumption restrictions in your region.
- Research limitations. Acknowledge that research on CBG and CBD is still evolving. Assure patients that all questions may not have definitive answers yet.
- Safety concerns. Evaluate the safety profile of CBG and CBD, noting potential risks and interactions.
Navigating legal and ethical considerations
What are the legal considerations for prescribing CBD and CBG? Australian practitioners should adhere to these regulations.
- Regional regulations. What’s the legal status of CBG and CBD in your jurisdiction? Laws around cannabis-derived products may vary regionally.
- Prescription guidelines. Get the approval of TGA or your territory’s Health Department to prescribe cannabinoids.²⁶
- Product compliance. Only recommend or prescribe products that comply with established regulations.
How do you ensure ethical CBD and CBG prescribing? Here are the key considerations.
- Informed consent. Seek your patient’s informed consent before prescribing cannabinoids to them.
- Manage expectations. Avoid making unrealistic promises about the efficacy of CBG and CBD.
- Prioritise patient well-being. The health and safety of your patients come before your professional interests.
Where do you find resources for legal updates and guidelines? Check out these sources.
- Government websites. Regularly check cannabinoid guidelines on the Office of Drug Control
- Professional associations. Regulatory bodies, medical boards, or medical cannabis groups are reliable.
- Accredited education sites. These platforms provide accurate, well-researched information. PlantEd is among the top-ranking sites.
- Legal experts. Work with experts knowledgeable about healthcare regulations and cannabis laws.
Venture into the world of medical cannabis with PlantEd
Every medical practitioner needs clinical guidance for CBD and CBG? These compounds are a goldmine when harnessed correctly.
Cannabinoids carry significant therapeutic potential. Scientists continue to study them as possible cures for pain, anxiety, and inflammation. There’s overwhelming clinical evidence to back the promise of these treatments.
Choose between CBG and CBD based on unique patient characteristics and targeted outcomes. You can personalise these remedies and optimise dosage. Study the patient’s history to identify contraindications for best results.
Continuing education for medical practitioners is crucial to improving treatment results. Basing treatment on facts helps educate patients and address misconceptions. You navigate legal and ethical considerations easily.
Ready to sail through the complexities of CBD vs. CBG? Sign up for accredited courses and join credible communities with PlantEd. We help our members cultivate medical cannabis knowledge through in-depth training. Contact us today to discover your options.
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